Related Experiment Video
Updated: May 8, 2026

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
Published on: May 16, 2019
First line management of prolonged convulsive seizures in children and adults: good practice points
Liesbeth De Waele1, Paul Boon, Berten Ceulemans
1Department of Paediatric Neurology, University Hospitals Leuven, 49 Herestraat, 3000, Leuven, Belgium, liesbeth.dewaele@uzleuven.be.
Insights
Rapidly stopping seizures is key to preventing status epilepticus. This paper outlines best practices for initial management of prolonged convulsive seizures before medical help arrives.
Area of Science:
- Neurology
- Emergency Medicine
- Pharmacology
Background:
- Status epilepticus (SE) is a medical emergency requiring rapid intervention.
- Prompt seizure termination is crucial for preventing long-term neurological damage.
- Benzodiazepines are the established first-line emergency medication for seizures.
Framework:
- This paper proposes "good practice points" for the pre-medical management of prolonged convulsive seizures.
- Focuses on initial interventions in a non-medical setting.
- Aims to standardize early-stage seizure management.
Implementation:
- Provides guidance for the first-line treatment of prolonged convulsive seizures.
- Covers both pediatric and adult populations.
- Emphasizes actions to be taken before the arrival of trained medical personnel.
Implications:
- Facilitates timely and effective emergency seizure management.
- Potentially reduces morbidity and mortality associated with status epilepticus.
- Empowers individuals to provide critical initial care during seizures.
Abstract:
Over the past decades, it has become clear that the most efficient way to prevent status epilepticus is to stop the seizure as fast as possible, and early treatment of prolonged convulsive seizures has become an integral part of the overall treatment strategy in epilepsy. Benzodiazepines are the first choice drugs to be used as emergency medication. This treatment in the early phases of a seizure often implies a 'pre-medical' setting before intervention of medically trained persons. In this paper, we propose "good practice points" for first line management of prolonged convulsive seizures in children and adults in a 'pre-medical' setting.
Related Concept Videos
Seizures l: Introduction
Seizures: Classification
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Epilepsy and Seizures: Overview
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Antiepileptic Drugs: Sodium Channel Blockers
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
Electroconvulsive Therapy

