Triazole-containing hydrogels for time-dependent sustained drug release.

Area of Science:

• Polymer Chemistry
• Materials Science
• Drug Delivery Systems

Background:

• Hydrogels are widely investigated for drug delivery applications.
• Controlling drug release kinetics remains a challenge in hydrogel-based systems.
• Triazole chemistry offers versatile platforms for material design.

Purpose of the Study:

• To synthesize novel triazole-containing hydrogels (TGs) for drug delivery.
• To investigate the sustained drug release capabilities of TGs.
• To explore the influence of pH and temperature on drug release.

Main Methods:

• Synthesis of HEMA-alkyne (HA) via DCC-coupling.
• Preparation of triazole-ring-containing monomer (TM) using click chemistry.
• Fabrication and characterization of various triazole-containing hydrogels (TGs).
• Drug release studies using Rhodamine 6G as a model drug.

Main Results:

• Successful synthesis of triazole-containing hydrogels (TGs).
• Demonstrated correlation between triazole ring aggregation and drug release control.
• Investigated the impact of pH and temperature on drug release profiles.
• Rhodamine 6G exhibited sustained release from the developed hydrogels.

Conclusions:

• Triazole-containing hydrogels (TGs) show promise as effective drug carriers.
• The aggregation of triazole rings is a key factor in modulating drug release.
• Sustained drug release can be tuned by environmental factors like pH and temperature.