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Related Concept Videos

Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...

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Related Experiment Video

Updated: May 8, 2026

In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse
04:14

In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse

Published on: October 6, 2023

Thyrotoxicosis in pregnancy:: A case report.

B R Kamath1, K J Rao, A A Mayadunne

  • 1Department of Medicine and.

Journal for Scientific Research. Medical Sciences
|September 11, 2013
PubMed
Summary

Hyperthyroidism in pregnancy can stem from hydatidiform moles, which cause excessive human chorionic gonadotropin (hCG). This case shows hyperthyroidism resolved after mole evacuation, highlighting a treatable cause of thyroid dysfunction during pregnancy.

Keywords:
hCGhydatidiform molepregnancythyrotoxicosis

Related Experiment Videos

Last Updated: May 8, 2026

In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse
04:14

In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse

Published on: October 6, 2023

Area of Science:

  • Obstetrics and Gynecology
  • Endocrinology
  • Reproductive Medicine

Background:

  • Hyperthyroidism complicates pregnancy with diverse etiologies, including Graves' disease and gestational thyrotoxicosis.
  • Elevated human chorionic gonadotropin (hCG) from trophoblastic tissue, such as in hydatidiform moles, can stimulate the thyroid.
  • Understanding hCG-mediated thyroid stimulation is crucial for managing pregnant patients.

Purpose of the Study:

  • To present a case of hyperthyroidism in pregnancy secondary to a hydatidiform mole.
  • To illustrate the resolution of hyperthyroidism following the evacuation of a hydatidiform mole.
  • To emphasize the importance of considering molar pregnancy in the differential diagnosis of hyperthyroidism during gestation.

Main Methods:

  • Case report of a pregnant patient.
  • Clinical presentation of hyperthyroidism.
  • Diagnosis of hydatidiform mole.
  • Management by mole evacuation.
  • Post-operative monitoring of thyroid function.

Main Results:

  • The patient presented with symptoms of hyperthyroidism.
  • A hydatidiform mole was diagnosed during pregnancy.
  • Following surgical evacuation of the mole, the patient's hyperthyroid state resolved.
  • Thyroid function normalized without further intervention.

Conclusions:

  • Hydatidiform mole is a significant, albeit less common, cause of hyperthyroidism in pregnancy.
  • Evacuation of the hydatidiform mole effectively treats the associated hyperthyroidism.
  • This case underscores the importance of timely diagnosis and management of molar pregnancies for maternal well-being.