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Z-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation

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Ovarian volume throughout life: a validated normative model.

Thomas W Kelsey¹, Sarah K Dodwell, A Graham Wilkinson

¹School of Computer Science, University of St Andrews, St Andrews, Fife, United Kingdom.

|September 11, 2013

Summary

This summary is machine-generated.

This study presents the first validated model of ovarian volume from conception to 82 years, revealing age as the primary factor. The model provides normative values for diagnosing gynecological conditions in females.

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Published on: September 3, 2021

Area of Science:

Reproductive endocrinology and gynaecology
Biostatistics and population modeling

Background:

Ovarian volume measurement is crucial for assessing ovarian reserve, reproductive disorders, and potential ovarian cancer screening.
Existing literature lacks a comprehensive normative model for ovarian volume across the lifespan.

Purpose of the Study:

To develop and validate the first normative model of ovarian volume from conception to 82 years of age.
To establish age-specific reference ranges for ovarian volume in females.

Main Methods:

A systematic literature search for published ovarian volume data in healthy females.
Integration of extensive personal data (n=59,994) from multiple sources.
Robust validation of a comprehensive life-course model for ovarian volume.

Main Results:

Age alone accounts for 69% of the variation in ovarian volume.
Ovarian volume increases from 0.7 mL at 2 years to a peak of 7.7 mL at 20 years.
Volume declines to approximately 2.8 mL at menopause and decreases further in older age.

Conclusions:

The developed model provides the first validated normative reference ranges for ovarian volume throughout a female's life.
This model is essential for the diagnosis and management of various gynaecological and reproductive conditions from birth through old age.