Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Pitted pattern in the human epididymis.

M Nistal¹, L Iñiguez, R Paniagua

¹Department of Morphology, School of Medicine, Autonomous University of Madrid, Spain.

Journal of Reproduction and Fertility

|July 1, 1990

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas.

Journal for immunotherapy of cancer·2019

Same author

Erythematous Pedunculated Papule on the Knee.

Actas dermo-sifiliograficas·2018

Same author

c-Kit identifies a subpopulation of mesenchymal stem cells in adipose tissue with higher telomerase expression and differentiation potential.

Differentiation; research in biological diversity·2014

Same author

Testicular maldescent and maldevelopment in fetal rats prenatally exposed to nitrofen.

Pediatric surgery international·2013

Same author

Ten novel mutations in the NR5A1 gene cause disordered sex development in 46,XY and ovarian insufficiency in 46,XX individuals.

The Journal of clinical endocrinology and metabolism·2012

Same author

IGFBP-3 methylation-derived deficiency mediates the resistance to cisplatin through the activation of the IGFIR/Akt pathway in non-small cell lung cancer.

Oncogene·2012

Same journal

Spermatogenesis and testicular tumours in ageing dogs.

Journal of reproduction and fertility·2000

Same journal

Effect of TNF-alpha on LH and IGF-I modulated chicken granulosa cell proliferation and progesterone production during follicular development.

Journal of reproduction and fertility·2000

Same journal

Uterine eosinophils and reproductive performance in interleukin 5-deficient mice.

Journal of reproduction and fertility·2000

Same journal

Follicular fluid rheology and the duration of the ovulatory process.

Journal of reproduction and fertility·2000

Same journal

Ultrasonography and hormone profiles of adrenocorticotrophic hormone (ACTH)-induced persistent ovarian follicles (cysts) in cattle.

Journal of reproduction and fertility·2000

Same journal

Identification of perivitelline N-linked glycans as mediators of sperm-egg interaction in chickens.

Journal of reproduction and fertility·2000

See all related articles

The human ductus epididymidis contains intra-epithelial cavities, forming pits. Their development is linked to androgens, suggesting an androgen-dependent process in male reproductive anatomy.

Area of Science:

Human histology
Reproductive biology
Andrology

Background:

The ductus epididymidis is crucial for sperm maturation and transport.
Its epithelial lining exhibits complex structures that can influence the microenvironment.

Purpose of the Study:

To investigate the histological characteristics of intra-epithelial cavities in the human ductus epididymidis.
To determine the potential role of androgens in the development of these cavities.

Main Methods:

Histological examination of human ductus epididymidis specimens from autopsy and surgical procedures.
Ultrastructural analysis of epithelial cells and cavity formation.
Correlation of pitted pattern presence with hormonal status (normal, precocious puberty, hypogonadotrophic hypogonadism).

Related Experiment Videos

Main Results:

Multiple intra-epithelial cavities/pits of varying development were identified.
Cavity formation involves changes in basal and principal epithelial cells.
A progressive increase in pitted areas from caput to corpus-cauda epididymidis was observed.
The pitted pattern was present in normal adults and children with precocious puberty, but absent in normal children and hypogonadal men.

Conclusions:

The development of pitted cavities in the ductus epididymidis is likely androgen-dependent.
This histological feature may play a role in the epididymis's function, potentially influenced by hormonal status.