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Updated: May 8, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates
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Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates

Published on: February 27, 2016

Sirtuin-3 (SIRT3) and the Hallmarks of Cancer

Turki Y Alhazzazi1, Pachiyappan Kamarajan, Eric Verdin

  • 1Division of Oral Biology, Oral Basic and Clinical Sciences Department, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia ; Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.

Genes & Cancer
|September 11, 2013
PubMed

Insights

Sirtuins, enzymes involved in aging and cancer, are increasingly studied for their roles in cancer hallmarks. This review focuses on SIRT3 as a potential cancer drug target.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Sirtuins (SIRT1-SIRT7) are mammalian homologs of yeast Sir2.
  • They are implicated in cancer biology and age-related diseases.
  • Known functions include roles in genomic stability, metabolism, and angiogenesis.

Purpose of the Study:

  • To review recent developments on sirtuins in cancer.
  • To highlight the role of SIRT3 in cancer hallmarks.
  • To discuss SIRT3 as a potential drug target for cancer treatment.

Main Methods:

  • Literature review of recent scientific publications.
  • Focus on studies investigating sirtuin family members, particularly SIRT3.
  • Analysis of sirtuin involvement in established cancer hallmarks.

Main Results:

  • Sirtuins play diverse roles in cancer development and progression.
  • SIRT3 is specifically linked to several key cancer hallmarks.
  • Emerging evidence suggests SIRT3's potential as a therapeutic target.

Conclusions:

  • Sirtuins, especially SIRT3, are critical regulators in cancer biology.
  • Targeting SIRT3 may offer novel therapeutic strategies for cancer treatment.
  • Further research is warranted to fully elucidate SIRT3's role and therapeutic potential.
Keywords:
SIRT3anoikiscancersirtuin-3sirtuinstumor promotertumor suppressor

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