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Pancreatic lipase inhibitory stilbenoids from the roots of Vitis vinifera
Young-Mog Kim1, Eun-Woo Lee, Sung-Hwan Eom
1Department of Food Science and Technology, Pukyong National University , Busan , Republic of Korea .
Abstract:
Bioassay-guided isolation of an aqueous methanolic extract of Vitis vinifera using pancreatic lipase inhibitory activity led to isolation of seven stilbenoids, wilsonol C (1), heyneanol A (2), ampelopsin A (3), pallidol A (4), cis-piceid (5), trans-piceid (6) and trans-resveratrol (7). The structures were established on the basis of NMR and MS spectroscopic data interpretation. All isolates were evaluated for their inhibitory effects on pancreatic lipase, and stilbenoid 1 exhibited potent inhibitory effect on pancreatic lipase with IC₅₀ values of 6.7 ± 0.7 µM.
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