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Related Experiment Video

Updated: May 8, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

Renal denervation: current implications and future perspectives.

Jianzhong Xu¹, Dagmara Hering, Yusuke Sata

¹*Neurovascular Hypertension & Kidney Disease Laboratory, Baker IDI Heart & Diabetes Institute, Melbourne, Australia.

Clinical Science (London, England : 1979)

|September 12, 2013

Summary

This summary is machine-generated.

Sympathetic nervous system (SNS) overactivity drives hypertension. Renal denervation offers a promising interventional approach for blood pressure control in resistant hypertension.

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Last Updated: May 8, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

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Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

Area of Science:

Cardiovascular Medicine
Nephrology
Interventional Cardiology

Background:

Sympathetic nervous system (SNS) activation is integral to arterial hypertension development and progression.
SNS overactivity correlates with various conditions like chronic renal failure, insulin resistance, and heart failure.
Pharmacological sympatholytic agents are underutilized, leaving SNS overactivity largely unaddressed in many patients.

Purpose of the Study:

To review the physiological role of renal nerves in hypertension and related diseases.
To summarize current clinical data on the safety and efficacy of renal denervation for resistant hypertension.
To discuss future implications and emerging devices for renal denervation.

Main Methods:

Review of existing literature on renal nerve physiology and hypertension.
Analysis of clinical studies evaluating catheter-based renal denervation.
Discussion of preliminary data from uncontrolled studies and ongoing trials.

Main Results:

Renal denervation demonstrates a clinically relevant blood pressure reduction in resistant hypertension patients.
The procedure exhibits a favorable vascular and renal safety profile.
Preliminary data in SNS-overactive disease states are promising but require further validation.

Conclusions:

Renal denervation is a viable therapeutic option for resistant hypertension by modulating renal nerve traffic.
Further well-designed clinical trials are necessary to confirm the efficacy and expand the application of renal denervation.
Newer devices are under investigation to optimize blood pressure control through renal denervation.