Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fetal Circulation01:14

Fetal Circulation

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Parentral Nutrition: Centeral and Peripheral Parental Nutrition01:27

Parentral Nutrition: Centeral and Peripheral Parental Nutrition

Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
Embryonic Connective Tissues01:20

Embryonic Connective Tissues

During early development, the embryo forms two types of connective tissues— the mesenchyme and mucoid connective tissue.
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development. Mesenchyme is...
Abdominal Regions and Quadrants01:19

Abdominal Regions and Quadrants

To promote clear communication, for instance, about the location of a patient's abdominal pain or a suspicious mass, anatomists and clinicians typically use imaginary lines to categorize the abdominopelvic cavity into either four quadrants or nine regions to identify organs in the cavity.
The simpler quadrants approach, which is more commonly used in medicine, subdivides the cavity with one horizontal and one vertical line that intersects at the patient's umbilicus (navel). The four quadrants...
Uterus and Cervix01:18

Uterus and Cervix

The uterus, commonly called the womb, is a vital reproductive organ in females designed to provide a nurturing environment for the implantation and growth of an embryo. It is shaped like a hollow pear and positioned between the urinary bladder and the rectum. The uterus's structure allows it to support and protect a developing fetus throughout pregnancy.
The uterus is securely anchored within the pelvic cavity by paired broad ligaments on either side. It is further stabilized by three pairs of...
Development of the Lymphatic System01:15

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comprehensive evaluation of cytomorphologic, histologic, and molecular features of DICER1-altered thyroid lesions on FNA: A multipractice experience.

Cancer cytopathology·2024
Same author

Placental Histologic Abnormalities and 2-Year Outcomes in Neonatal Hypoxic-Ischemic Encephalopathy.

Neonatology·2023
Same author

The Placenta Pathology Tool: an online application for understanding histopathologic lesions.

American journal of obstetrics and gynecology·2023
Same author

Neonatologist responsibility to ensure placentas are received for pathologic examination-response to comment on criteria for placental examination for obstetric and neonatal providers.

American journal of obstetrics and gynecology·2023
Same author

Criteria for placental examination for obstetrical and neonatal providers.

American journal of obstetrics and gynecology·2022
Same author

Placental pathology is necessary to understand common pregnancy complications and achieve an improved taxonomy of obstetrical disease.

American journal of obstetrics and gynecology·2022

Related Experiment Video

Updated: May 8, 2026

Isolation of Umbilical Cord-Derived Mesenchymal Stem Cells with High Yields and Low Damage
04:47

Isolation of Umbilical Cord-Derived Mesenchymal Stem Cells with High Yields and Low Damage

Published on: July 5, 2024

Peripheral insertion of umbilical cord.

Guangju Luo1, Raymond W Redline

  • 11  Department of Pathology, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH, USA.

Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
|September 12, 2013
PubMed
Summary

Peripheral insertion of umbilical cord (PIUC) is linked to premature birth and altered placental development. This condition may indicate a primary developmental issue rather than secondary migration.

More Related Videos

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas
09:04

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas

Published on: September 5, 2011

Related Experiment Videos

Last Updated: May 8, 2026

Isolation of Umbilical Cord-Derived Mesenchymal Stem Cells with High Yields and Low Damage
04:47

Isolation of Umbilical Cord-Derived Mesenchymal Stem Cells with High Yields and Low Damage

Published on: July 5, 2024

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas
09:04

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas

Published on: September 5, 2011

Area of Science:

  • Obstetrics and Gynecology
  • Developmental Biology
  • Pathology

Background:

  • Marginal and membranous umbilical cord (UC) insertions are recognized complications.
  • Eccentric UC insertion, specifically peripheral insertion of UC (PIUC), warrants further investigation for its clinical significance.

Purpose of the Study:

  • To assess the relevance of peripheral insertion of UC (PIUC), defined as insertion <3 cm from the nearest margin.
  • To determine the association of PIUC with adverse pregnancy outcomes and placental characteristics.

Main Methods:

  • A case-control study analyzed 1418 singleton placentas over 18 months.
  • PIUC cases (n=119) were matched with controls; marginal/membranous insertions and multiple gestations were excluded.

Main Results:

  • PIUC prevalence was 8.4%, significantly higher in premature births (<28 weeks, 21.4%).
  • PIUC associated with decreased placental weight Z-score and elongated placentas, suggesting increased placental reserve utilization.
  • PIUC more frequent in young primiparous mothers and less common after curettage.

Conclusions:

  • PIUC is significantly associated with premature birth and altered placental morphology.
  • Findings support PIUC as a primary developmental disorder.
  • No significant association found with most adverse pregnancy outcomes or placental lesions, except borderline maternal malperfusion.