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Liquorice root extracts as potent cariostatic agents in pediatric practice
Eesha Jain1, Ramesh K Pandey, Richa Khanna
1Department of Pedodontics, Faculty of Dental Sciences, King George's Medical University, Lucknow, Uttar Pradesh, India.
Journal of the Indian Society of Pedodontics and Preventive Dentistry
|September 12, 2013
Summary
Aqueous and ethanolic liquorice extracts show potent cariostatic effects against mutans streptococci, with good palatability in children. These natural agents offer promising dental caries prevention.
Area of Science:
- Oral Health
- Natural Products Chemistry
- Microbiology
Background:
- Dental caries remains a significant global health issue, particularly among children.
- Mutans streptococci are primary etiological agents in dental caries development.
- Natural compounds are increasingly explored for their therapeutic potential in oral hygiene.
Purpose of the Study:
- To evaluate the in vitro and in vivo cariostatic efficacy of aqueous and ethanolic liquorice extracts.
- To assess the acceptability and palatability of liquorice mouthwashes among pediatric patients.
- To compare the effects of liquorice extracts with chlorhexidine gluconate as a positive control.
Main Methods:
- Minimum bactericidal concentrations of liquorice extracts against mutans streptococci were determined.
- Toxicity profiles were assessed using Caenorhabditis elegans.
- A double-blind pilot study involved 60 pediatric patients using liquorice or chlorhexidine mouthwashes, with saliva analysis for pH and bacterial counts.
Main Results:
- Both liquorice extracts demonstrated significant reduction in mutans streptococci colony counts immediately post-rinsing.
- The ethanolic liquorice extract showed a significant reduction compared to the positive control.
- Salivary pH increased immediately after rinsing with liquorice extracts, indicating antimicrobial action with limited retentivity.
Conclusions:
- Aqueous and ethanolic liquorice extracts are effective cariostatic agents.
- Liquorice extracts were found to be palatable by child patients.
- These findings support the potential use of liquorice extracts in preventing dental caries.
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