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Malakoplakia with digestive tract involvement in a pig.
D Gelmetti1, L Gibelli2, L Gelmini2
1Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, Brescia, Italy daniela.gelmetti@izsler.it.
Veterinary Pathology
|September 12, 2013
Summary
A rare inflammatory disease called malakoplakia was found in a pig. This condition, characterized by Michaelis-Gutmann bodies, mimicked a tumor but had no detectable infectious cause.
Area of Science:
- Veterinary Pathology
- Comparative Pathology
- Inflammatory Diseases
Background:
- Malakoplakia is a rare granulomatous inflammatory condition.
- It can mimic malignant neoplasms and affect various organs.
- This case involves a 10-month-old slaughter pig.
Observation:
- Gross examination revealed tumor-like infiltrates in the stomach, pancreas, omentum, and mesenteric lymph nodes.
- Histopathological analysis showed diffuse, pleomorphic round cell infiltrates, primarily histiocytes.
- Characteristic Michaelis-Gutmann bodies (concentric inclusions) were observed within histiocytes and multinucleated giant cells.
Findings:
- No microorganisms were identified using various special stains (PAS, Ziehl-Neelsen, Gram, Warthin-Starry), electron microscopy, or bacteriologic culture.
- Immunohistochemistry ruled out Porcine circovirus type 2 and Porcine reproductive and respiratory syndrome virus infections.
- The etiology of malakoplakia in this case remained undetermined.
Implications:
- This case expands the understanding of malakoplakia's presentation in swine.
- It highlights the importance of considering malakoplakia in differential diagnoses for tumor-like lesions in pigs.
- Further research may be needed to elucidate the pathogenesis of non-infectious malakoplakia in animals.
