Ambient air pollution and preeclampsia: a spatiotemporal analysis
Payam Dadvand1, Francesc Figueras, Xavier Basagaña
1Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
Environmental Health Perspectives
|September 12, 2013
Summary
Exposure to fine particulate air pollution increases the risk of preeclampsia, particularly late-onset preeclampsia in the third trimester. Early-onset preeclampsia risk is linked to first-trimester exposure to fine particulate matter (PM2.5).
Area of Science:
- Environmental Health
- Obstetrics and Gynecology
- Epidemiology
Background:
- Limited evidence exists on air pollution's link to preeclampsia.
- Specific associations with early- and late-onset preeclampsia remain understudied.
Purpose of the Study:
- To investigate associations between preeclampsia (all, early-, and late-onset) and various air pollutants.
- To assess exposure during the entire pregnancy and specific trimesters.
Main Methods:
- Study included 8,398 pregnancies in Barcelona (2000-2005).
- Spatiotemporal exposure assessment used land use regression models.
- Logistic and conditional logistic regression analyzed associations.
Main Results:
- Positive associations found between air pollution and preeclampsia.
- Strongest links for late-onset preeclampsia with third-trimester fine particulate matter (PM2.5) exposure.
- Early-onset preeclampsia showed associations with first-trimester PM2.5 exposure.
Conclusions:
- Fine particulate air pollution is associated with an increased risk of preeclampsia.
- Findings support further research into distinct pathogenic mechanisms for early- and late-onset preeclampsia.
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