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Association between EEG abnormalities and CSF biomarkers in a memory clinic cohort
Milica Gregoric Kramberger1, Ingemar Kåreholt, Thomas Andersson
1Department of Neurobiology, Care Sciences and Society, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Background:
The aim of the study was to describe distinct electroencephalogram (EEG) phenotypes defined after routine visual EEG analysis in a large memory clinic cohort and to investigate their relationship to cerebrospinal fluid (CSF) biomarkers.
Methods:
Patients with Alzheimer's disease (n = 131), mild cognitive impairment (n = 285), subjective cognitive impairment (n = 310), and mixed dementia (n = 29) were assessed clinically with neuroimaging, EEG and CSF investigations. EEG phenotypes were based on frequency of background activity (BA) and presence and degree of episodic abnormalities (EA).
Results:
BA and EA differed significantly (p < 0.001) between diagnostic groups. A lower CSF amyloid β42/phospho-tau ratio and higher total tau were associated with slower BA (p < 0.01) and a higher degree of EA (p < 0.04).
Conclusions:
Slowing of BA in combination with EA seems to be related to biological markers of neurodegeneration.
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