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Related Concept Videos

Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Dysrhythmias VI: Management of Dysrhythmias01:25

Dysrhythmias VI: Management of Dysrhythmias

Dysrhythmia management involves a multifaceted approach, incorporating pharmacological treatments, medical procedures, surgical interventions, lifestyle modifications, and patient education.Pharmacological ManagementAntiarrhythmic Drugs:Class I (Sodium Channel Blockers): This class includes quinidine and procainamide, which reduce the speed of impulse conduction in the heart, stabilize the cardiac membrane, and control arrhythmias. Quinidine and procainamide are Class IA agents that prolong the...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

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Related Experiment Video

Updated: May 8, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

New developments in cardiac resynchronization therapy.

Rajiv Sankaranarayanan1, Rajaverma Visweswariah, David J Fox

  • 1Cardiology Specialist Registrar in Electrophysiology and British Heart Foundation Clinical Research Fellow, University Hospital South Manchester and University of Manchester, Manchester.

British Journal of Hospital Medicine (London, England : 2005)
|September 12, 2013
PubMed
Summary
This summary is machine-generated.

Cardiac resynchronization therapy (CRT) greatly lowers death and illness in heart failure patients with ventricular dyssynchrony. This review covers recent advances and future directions in this evolving medical field.

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Last Updated: May 8, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Area of Science:

  • Cardiology
  • Medical Technology

Background:

  • Heart failure (HF) affects millions globally, often accompanied by ventricular dyssynchrony.
  • Ventricular dyssynchrony impairs cardiac efficiency and worsens HF prognosis.
  • Current treatments for HF have limitations, necessitating advanced therapeutic strategies.

Purpose of the Study:

  • To review the current evidence supporting cardiac resynchronization therapy (CRT) in HF patients.
  • To discuss recent technological and clinical advances in CRT.
  • To explore future directions and potential innovations in CRT.

Main Methods:

  • Comprehensive literature search of peer-reviewed studies on CRT.
  • Analysis of clinical trial data and observational studies.
  • Synthesis of information on device technology and patient selection.

Main Results:

  • CRT significantly reduces mortality and morbidity in selected HF patients with ventricular dyssynchrony.
  • Patient selection based on electrocardiogram (ECG) and imaging criteria improves CRT response rates.
  • Technological advancements are enhancing CRT delivery and efficacy.

Conclusions:

  • CRT is a cornerstone therapy for eligible HF patients, improving outcomes.
  • Ongoing research focuses on optimizing patient selection and device technology.
  • Future CRT strategies may involve leadless pacing and multi-point stimulation for broader patient benefit.