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Related Experiment Video

Updated: May 8, 2026

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

Shaking head means "no".

Stefan Weiler¹, Alexander Offinger, Aristomenis K Exadaktylos

¹Department of General Internal Medicine, Inselspital, University Hospital Bern, Bern, Switzerland.

BMJ Case Reports

|September 12, 2013

Summary

Sumatriptan and venlafaxine can cause serotonin syndrome, a serious condition with symptoms like head twitching and muscle spasms. Promptly stopping these drugs and using benzodiazepines can resolve symptoms.

Area of Science:

Neurology
Clinical Pharmacology

Background:

A 45-year-old male presented with head twitching and myoclonic movements.
The patient was on long-term venlafaxine for depression and self-medicating with sumatriptan for post-accident head pain.

Observation:

The patient exhibited hypertension, tachycardia, dyskinesia, and spontaneous myoclonic movements.
Cranial CT and cervical spine imaging ruled out trauma-related injuries.

Findings:

Symptoms resolved after discontinuing sumatriptan and venlafaxine, and administering lorazepam.
This case highlights the potential for drug interactions leading to serotonin syndrome.

Implications:

Serotonin syndrome requires high diagnostic suspicion, especially in patients on multiple serotonergic agents.

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Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

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Management involves drug withdrawal and symptomatic treatment with benzodiazepines.