Related Experiment Video For Gastritis
Updated: May 8, 2026

Mouse Models Of Helicobacter Infection And Gastric Pathologies
Published on: October 18, 2018
Effects of dietary calcium on Helicobacter pylori-induced gastritis in Mongolian gerbils
Masaki Iimuro1, Shiro Nakamura, Tetsuo Arakawa
1Division of Cancer Prevention Research, National Cancer Center Research Institute, 1-1, Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, Japan. mimutoh@ncc.go.jp.
Background And Aims:
Helicobacter pylori (Hp) infection causes gastritis and is considered a gastric cancer risk factor. We have previously reported that codfish meal markedly enhanced Hp-induced gastritis in Mongolian gerbils. In the present study, we sought the responsible components in codfish meal.
Materials And Methods:
Codfish were divided into three parts (meat, viscera and 'other parts', including bone), and administered to Hp-infected gerbils. Subsequently, cod bone, sardine bone and prawn shell were tested, along with major calcium components, hydroxyapatite and calcium carbonate, in bone and shell, respectively.
Results:
'Other parts' and cod bone enhanced Hp-induced gastritis, as was observed for whole codfish. Similarly, sardine bone and prawn shell, as well as 0.22-0.88% hydroxyapatite and calcium carbonate, enhanced gastritis. In contrast, administration of a higher dose of the calcium compounds exerted protective effects.
Conclusion:
Intake of calcium compounds may contribute to enhancement of Hp-induced gastritis.
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