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Published on: September 26, 2013
Role of leptin in autoimmune diseases
Manole Cojocaru1, Inimioara Mihaela Cojocaru, Isabela Siloşi
1"Titu Maiorescu" University, Faculty of Medicine, Department of Physiology, "Dr. Ion Stoia" Center for Rheumatic Diseases, Bucharest, Romania.
Abstract:
Leptin represents a link between metabolism, nutritional status, and immune responses. Leptin is important for optimal functioning of the immune system. Leptin is a cytokine-like hormone with proinflammatory properties linked to autoimmune diseases. Moreover, there has been increasing evidence that leptin is involved in the pathogenesis of various autoimmune diseases. Leptin has been shown to enhance immune reactions in autoimmune diseases that are commonly associated with inflammatory responses. Both high and low levels of leptin might contribute to autoimmune diseases. Leptin has been explored as a potential target for therapeutic development in treating autoimmune diseases. In this review, we review here the most recent advances on the role of leptin in autoimmunity and in immune-rheumatological diseases.
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