Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Uncontrollability of experimental pain decreases pain intensity and relief pleasantness ratings in a between-group design.

Pain reports·2026
Same author

Acute placebo responsiveness predicts longitudinal expectation effects in antidepressant treatment.

Translational psychiatry·2026
Same author

Temporal predictions shape somatosensory perception.

Nature communications·2026
Same author

Factors Associated With Self-Medication to Mitigate Vaccine Reactions After COVID-19 Vaccination: A Prospective Cohort Study.

Pharmacoepidemiology and drug safety·2026
Same author

Auditory Hyperresponsivity in Chronic Back Pain: A Randomized Controlled Trial of Pain Reprocessing Therapy.

Annals of neurology·2026
Same author

Neural dynamics during heat pain threshold assessment using the method of limits.

NeuroImage·2025

Related Experiment Video

Updated: May 8, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

Elevated functional connectivity in a striatal-amygdala circuit in pathological gamblers.

Jan Peters1, Stephan Franz Miedl, Christian Büchel

  • 1Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany ; Helen Wills Neuroscience Institute, University of California, Berkeley, California, United States of America.

Plos One
|September 12, 2013
PubMed
Summary

Pathological gambling (PG) shows increased functional connectivity between the striatum and amygdala, similar to other impulse control disorders (ICDs). These findings link gambling disorder to addiction mechanisms involving brain circuitry.

More Related Videos

Transcranial Direct Current Stimulation for Online Gamers
06:01

Transcranial Direct Current Stimulation for Online Gamers

Published on: November 9, 2019

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

Related Experiment Videos

Last Updated: May 8, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

Transcranial Direct Current Stimulation for Online Gamers
06:01

Transcranial Direct Current Stimulation for Online Gamers

Published on: November 9, 2019

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

Area of Science:

  • Neuroscience
  • Psychiatry
  • Addiction Research

Background:

  • Substance-based addiction and impulse control disorders (ICDs) involve ventral striatum dysfunction.
  • Previous research indicates altered functional connectivity between the ventral striatum and limbic regions in substance use disorders and ADHD.

Purpose of the Study:

  • To investigate functional connectivity effects in pathological gambling (PG) using existing fMRI data.
  • To determine if PG exhibits similar functional connectivity patterns as observed in other ICDs and substance use disorders.

Main Methods:

  • Re-analysis of previously published functional magnetic resonance imaging (fMRI) data.
  • Data acquired during value-based decision-making tasks in pathological gamblers and control participants.
  • Functional connectivity analysis focusing on the striatum and limbic regions.

Main Results:

  • Pathological gamblers demonstrated significantly increased functional coupling between the striatum and bilateral amygdala compared to controls.
  • Findings align with previous studies on functional connectivity in other ICDs.

Conclusions:

  • Pathological gambling is associated with altered neural connectivity, specifically involving the striatum-amygdala pathway.
  • These results support the integration of gambling disorder within broader models of addiction and impaired self-control.
  • The findings contribute to understanding the neurobiological underpinnings of behavioral addictions.