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[The management of systemic lupus erythematosus with biological therapies]

O Malaise1, C von Frenckell, B André

  • 1Service de rhumatologie, CHU de Liege, Sart Tilman, 4000 Liège, Belgique. michel.malaise@ulg.ac.be

Revue Medicale Suisse
|September 13, 2013
PubMed

The efficacy and safety of targeted biological therapies have been analyzed in patients suffering from systemic lupus erythematosus. In renal lupus, infliximab has shown prolonged improvement of the renal function after the induction period (small open studies), whereas abatacept had no significant efficacy (randomised controlled study). In renal and non renal lupus, rituximab did not confirm its efficacy in two randomised controlled studies. In non renal lupus, epratuzumab has shown efficacy in a phase IIb. Belimumab at the high posology of 10 mg/kg has also shown significant efficacy in two large randomised controlled studies.

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