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DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Temperature-activated nucleic acid nanostructures.

Ke Zhang¹, Xiao Zhu, Fei Jia

¹Department of Chemistry and Chemical Biology, Northeastern University , 360 Huntington Ave, Boston, Massachusetts 02115, United States.

Journal of the American Chemical Society

|September 13, 2013

Summary

This summary is machine-generated.

Researchers developed temperature-responsive DNA-polymer hybrid nanoparticles. Heating exposes DNA for hybridization and biotin accessibility, while cooling blocks these functions, enabling controllable surface chemistry.

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Area of Science:

Nanotechnology
Materials Science
Biochemistry

Background:

Gold nanoparticles (AuNPs) are versatile platforms for various applications.
Poly(N-isopropylacrylamide) (PNIPAM) exhibits temperature-dependent solubility.
DNA nanotechnology offers precise control over molecular assembly and function.

Purpose of the Study:

To co-assemble DNA and PNIPAM onto gold nanoparticles.
To create a temperature-responsive system for controlling DNA accessibility and surface chemistry.
To demonstrate the on-off switching of surface function based on temperature cues.

Main Methods:

Co-assembly of DNA and PNIPAM onto gold nanoparticles.
Utilizing temperature changes (around 30 °C) to induce conformational changes in PNIPAM.
Monitoring DNA hybridization and biotin accessibility using complementary strands and temperature shifts.

Main Results:

Successful co-assembly of DNA and PNIPAM on gold nanoparticles.
Reversible exposure and hiding of DNA sequences in response to temperature.
Demonstrated on-off switching of surface chemistry, with DNA hybridization and biotin accessibility activated upon heating and blocked upon cooling.

Conclusions:

The developed DNA-PNIPAM-gold nanoparticle system provides a novel temperature-triggered platform.
This system allows for precise control over surface chemistry and function.
Potential applications in drug delivery, sensing, and responsive materials are suggested.