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Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...

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Updated: May 8, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

Problems experienced by older people when opening medicine packaging.

Daphne Philbert1, Kim Notenboom, Marcel L Bouvy

  • 1UPPER, Division of Pharmacoepidemiology & Clinical Pharmacology, Utrecht University, Utrecht.

The International Journal of Pharmacy Practice
|September 13, 2013
PubMed
Summary

Nearly 30% of older adults struggle to open omeprazole packaging, with peel-off blisters posing the greatest challenge. Many patients develop workarounds, but improved packaging design and pharmacy guidance are needed.

Keywords:
ageddrug containersdrug packagingelderlyomeprazole

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Oral Health Assessment by Lay Personnel for Older Adults
08:47

Oral Health Assessment by Lay Personnel for Older Adults

Published on: February 2, 2020

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Last Updated: May 8, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

Oral Health Assessment by Lay Personnel for Older Adults
08:47

Oral Health Assessment by Lay Personnel for Older Adults

Published on: February 2, 2020

Area of Science:

  • Geriatric medicine
  • Pharmaceutical packaging science
  • Patient adherence studies

Background:

  • Medicine packaging can present significant challenges for elderly individuals in their daily routines.
  • Difficulty in opening medication containers can impact treatment adherence and quality of life for older adults.

Purpose of the Study:

  • To determine the prevalence of problems older adults face when opening omeprazole packaging.
  • To explore the strategies patients employ to manage difficulties with medicine packaging.

Main Methods:

  • A study involving 30 community pharmacies and 317 patients aged 65 and above with omeprazole prescriptions.
  • Data collected via telephone questionnaires regarding packaging type and opening difficulties.

Main Results:

  • 28.4% of patients reported issues opening their omeprazole packaging, with peel-off blister packs causing the most problems (66.7%).
  • Patients using peel-off and push-through blister packs had a significantly higher risk of experiencing opening difficulties compared to those using bottles.
  • Two-thirds of patients utilized management strategies, with higher reporting for bottle and push-through blister issues.

Conclusions:

  • A substantial proportion of older patients encounter difficulties with omeprazole packaging, highlighting a need for user-centered design.
  • Not all patients experiencing packaging problems have established management strategies, emphasizing the importance of patient education and support.
  • Pharmaceutical manufacturers should prioritize packaging user-friendliness, and pharmacy staff should provide clear instructions and assistance to patients.