Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long vs. short axial field-of-view PET scanners for brain imaging: a phantom study.

Frontiers in nuclear medicine·2026
Same author

Current status of radionuclide therapy targeting PARP in cancer: challenges and prospects.

European journal of nuclear medicine and molecular imaging·2026
Same author

In vivo bacteria-targeted imaging with vancomycin-based positron emission tomography and optical tracers in an orthopaedic trauma implant infection model.

European journal of nuclear medicine and molecular imaging·2026
Same author

In vivo PET imaging of zebrafish and its application for detecting metabolic changes in response to lipopolysaccharide.

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology·2026
Same author

[<sup>18</sup>F]FDG interactions with human serum albumin: Binding and molecular modeling studies.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2026
Same author

Validation of a Deep-Learning Coregistration Framework for Long-Axial-Field-of-View PET/CT Using Low-Radiation-Exposure Protocols Across Various Tracers.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026

Related Experiment Video

Updated: May 8, 2026

Enhancing Efficiency and Radiolabeling Yields of Carbon-11 Radioligands for Clinical Research Using the Loop Method
09:08

Enhancing Efficiency and Radiolabeling Yields of Carbon-11 Radioligands for Clinical Research Using the Loop Method

Published on: December 20, 2024

Small molecule PET-radiopharmaceuticals.

Philip H Elsinga, Rudi A J O Dierckx1

  • 1University Medical Center Groningen, University of Groningen, the Netherlands and Ghent University, Belgium. p.h.elsinga@umcg.nl.

Current Pharmaceutical Design
|September 13, 2013
PubMed
Summary

Developing small molecule Positron Emission Tomography (PET) tracers requires careful consideration of design and selection criteria. This review covers key radiochemistry principles, trends, and regulatory updates for novel PET tracer development.

More Related Videos

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

Optimization of Radiochemical Reactions using Droplet Arrays
10:54

Optimization of Radiochemical Reactions using Droplet Arrays

Published on: February 12, 2021

Related Experiment Videos

Last Updated: May 8, 2026

Enhancing Efficiency and Radiolabeling Yields of Carbon-11 Radioligands for Clinical Research Using the Loop Method
09:08

Enhancing Efficiency and Radiolabeling Yields of Carbon-11 Radioligands for Clinical Research Using the Loop Method

Published on: December 20, 2024

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

Optimization of Radiochemical Reactions using Droplet Arrays
10:54

Optimization of Radiochemical Reactions using Droplet Arrays

Published on: February 12, 2021

Area of Science:

  • Radiochemistry and Molecular Imaging

Background:

  • Small molecule Positron Emission Tomography (PET) tracers are crucial for in vivo molecular imaging.
  • Development of novel PET tracers necessitates a multidisciplinary approach, integrating chemistry, biology, and regulatory science.

Purpose of the Study:

  • To provide a comprehensive overview of essential aspects for developing small molecule PET tracers.
  • To summarize current principles and trends in carbon-11 ((11)C) and fluorine-18 ((18)F) radiochemistry.
  • To update on recent regulatory developments impacting PET tracer development.

Main Methods:

  • Review of established and emerging methodologies in small molecule PET tracer design.
  • Summary of key considerations in (11)C and (18)F radiolabeling strategies.
  • Analysis of current regulatory guidelines and their implications for tracer development.

Main Results:

  • Identified critical design and selection criteria for successful PET tracer development.
  • Highlighted the latest advancements and challenges in (11)C and (18)F radiochemistry.
  • Provided insights into evolving regulatory landscapes affecting clinical translation.

Conclusions:

  • Strategic planning in design and selection is paramount for efficient PET tracer development.
  • Understanding radiochemistry principles and regulatory requirements is essential for advancing the field.
  • This review serves as a guide for researchers navigating the complexities of small molecule PET tracer creation.