Small molecule PET-radiopharmaceuticals
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Updated: May 8, 2026

Enhancing Efficiency and Radiolabeling Yields of Carbon-11 Radioligands for Clinical Research Using the Loop Method
Published on: December 20, 2024
Philip H Elsinga, Rudi A J O Dierckx1
1University Medical Center Groningen, University of Groningen, the Netherlands and Ghent University, Belgium. p.h.elsinga@umcg.nl.
Abstract:
This review describes several aspects required for the development of small molecule PET-tracers. Design and selection criteria are important to consider before starting to develop novel PET-tracers. Principles and latest trends in (11)C and (18)F-radiochemistry are summarized. In addition an update of some new developments in regulatory aspects is supplied.
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