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Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...

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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

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Published on: March 17, 2023

Maternal screening for hypothyroidism and thyroiditis using filter paper specimens.

T P Foley1, J J Henry, L F Hofman

  • 11 Emeritus Professor, University of Pittsburgh , Department of Pediatrics, School of Medicine, Department of Epidemiology, Graduate School of Public Health, Post Office Box 38472, Pittsburgh, Pennsylvania.

Journal of Women'S Health (2002)
|September 13, 2013
PubMed
Summary
This summary is machine-generated.

Screening pregnant and postpartum women for thyroid disorders using filter paper blood tests is effective. Thyroid-stimulating hormone (TSH) and thyroid antibodies (TAb) accurately detect hypothyroidism and autoimmune thyroiditis.

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Area of Science:

  • Endocrinology
  • Reproductive Medicine
  • Clinical Diagnostics

Background:

  • Thyroid dysfunction, including hypothyroidism and autoimmune thyroiditis, is common in pregnant and postpartum women.
  • These conditions pose risks to both maternal and fetal health.
  • Early detection and management are crucial.

Purpose of the Study:

  • To evaluate the efficacy and accuracy of screening pregnant and postpartum women for primary hypothyroidism and autoimmune thyroiditis.
  • To assess the utility of testing thyroid-stimulating hormone (TSH) and thyroid antibodies (TAb) in filter paper eluates.

Main Methods:

  • A prospective study enrolled 494 first-trimester pregnant women.
  • Finger-prick blood on filter paper was tested for TSH and TAb.
  • 178 women were also tested postpartum, with abnormal results confirmed by serum tests.

Main Results:

  • 18.4% of pregnant and 24.2% of postpartum women had abnormal TSH and/or TAb.
  • 28.3% of pregnant women had elevated TSH (>2.5 mU/L).
  • 18 women (3.6%) showed abnormal results postpartum after normal pregnancy tests.

Conclusions:

  • TSH and thyroperoxidase antibodies (TPOAb) in filter paper eluates are effective screening tools.
  • These tests accurately detect hypothyroidism and autoimmune thyroiditis in pregnant and postpartum women.
  • Results correlate well with traditional serum testing methods.