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Related Concept Videos

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
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Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
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Assessment of the Rectum and Anus

Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
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Related Experiment Video

Updated: May 8, 2026

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice
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Published on: March 20, 2017

Postmortem examination in the morbidly obese.

Eve Fryer1, Ian S D Roberts, Mary N Sheppard

  • 1Department of Cellular Pathology, John Radcliffe Hospital, Oxford, UK.

Histopathology
|September 13, 2013
PubMed
Summary
This summary is machine-generated.

Pathologists often miss obesity as a cause of death in morbidly obese individuals during postmortems. Improved recognition of obesity

Keywords:
body mass indexobesitypostmortems

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Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
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Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
08:30

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07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Area of Science:

  • Forensic Pathology
  • Public Health
  • Obesity Research

Background:

  • Rising incidence of obesity and its association with increased mortality.
  • Pathologists will increasingly perform postmortems on morbidly obese individuals.
  • Essential for pathologists to recognize morbid obesity and its postmortem consequences.

Purpose of the Study:

  • Assess the frequency of obesity inclusion in the cause of death for morbidly obese individuals.
  • Determine if obesity-related causes of death are being overlooked in postmortem reports.

Main Methods:

  • Retrospective analysis of medicolegal postmortem database (John Radcliffe Hospital, Jan 2007-Sep 2012).
  • Identification of postmortems performed on morbidly obese individuals (BMI ≥ 40 kg/m²).
  • Review of medical certificates of cause of death for obesity inclusion.

Main Results:

  • 202 postmortems (5.2% of 4742) were on morbidly obese individuals.
  • Obesity was listed as a cause of death in only 22% (41/189) of natural deaths.
  • Significant percentage of postmortems involved morbidly obese individuals.

Conclusions:

  • Postmortems on morbidly obese individuals are a significant and distinct group.
  • Recognition of obesity's contribution to death and associated conditions is inadequate.
  • Pathologists need specific approaches for postmortems in the morbidly obese.