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Related Concept Videos

Vaccinations01:51

Vaccinations

Overview
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Vaccine Production01:23

Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Pharmacovigilance01:19

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...

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Vaccine acceptance: the UK perspective.

John A Ford1, Hamid Mahgoub2, Ananda Giri Shankar2

  • 1Academic Clinical Fellow in Public Health; University of East Anglia; Norwich, Norfolk, UK.

Human Vaccines & Immunotherapeutics
|September 13, 2013
PubMed
Summary
This summary is machine-generated.

UK vaccine acceptance varies, with pertussis in pregnant women successful but influenza in healthcare workers poor. Historical skepticism and media influence impact uptake of vaccines like MMR, rotavirus, and shingles.

Keywords:
MMRUKinfluenzapertussisrotavirusshinglesvaccine acceptance

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Area of Science:

  • Public Health
  • Vaccinology
  • Health Policy

Background:

  • Historical vaccine acceptance in the UK traces back to Edward Jenner.
  • The MMR vaccine faces ongoing skepticism due to the discredited 1998 Wakefield study.
  • Vaccine uptake shows disparities, with pertussis in pregnant women more successful than influenza vaccination.

Purpose of the Study:

  • To examine vaccine acceptability in the UK.
  • To analyze factors influencing vaccine uptake, including media and policy.
  • To predict the impact on future vaccine introductions.

Main Methods:

  • Review of historical vaccine acceptance data.
  • Analysis of factors influencing uptake of specific vaccines (MMR, pertussis, influenza).
  • Consideration of media, political, and health reform influences.

Main Results:

  • Pertussis vaccination in pregnant women shows higher success rates compared to influenza vaccination.
  • Influenza vaccine uptake among healthcare workers remains suboptimal.
  • Mixed coverage for various vaccines is influenced by media, politicians, and health reforms.

Conclusions:

  • Vaccine acceptability in the UK is complex, influenced by historical events and public perception.
  • Future vaccine introductions, such as rotavirus and shingles, may face similar challenges.
  • Understanding these dynamics is crucial for effective public health strategies.