Related Experiment Video
Updated: May 8, 2026

4-Dimensional Imaging of Zebrafish Optic Cup Morphogenesis
Published on: May 26, 2021
The ciliary marginal zone (CMZ) in development and regeneration of the vertebrate eye
Andy J Fischer1, Jennifer L Bosse, Heithem M El-Hodiri
1Department of Neuroscience, The Ohio State University, USA; Graduate Program in Molecular, Cellular, and Developmental Biology, The Ohio State University, USA.
Abstract:
The ciliary marginal zone (CMZ) is a circumferential ring of cells found at the extreme periphery of the maturing and mature neural retina that consists of retinal stem and progenitor cells. It functions to add retinal neurons to the periphery of the neural retina in larval and adult fish, larval frogs, and birds. Additionally, the CMZ may contribute to regeneration of the damaged retina in frogs and fish. In mammals, cells from the ciliary epithelium can be induced to express retinal stem cell-like characteristics in culture but may not comprise a classically defined CMZ.
More Related Videos
Related Concept Videos
Anatomy of the Eyeball
Microtubules in Signaling
Mechanism of Ciliary Motion
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
Mechanism of Ciliary Motion
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...

