Related Experiment Video
Updated: May 8, 2026
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Sudden sensorineural hearing loss associated with chronic periodontitis: a population-based study
Chuan-Song Wu1, Tzong-Hann Yang, Herng-Ching Lin
1*Department of Otolaryngology, Taipei City Hospital; †School of Health Care Administration, ‡Department of Neurology, and §Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University; ∥Department of Neurosurgery, Taipei City Hospital; and ¶Community Medicine Research Center and Institute of Public Health, National Yang-Ming University, Taipei, Taiwan, Republic of China.
Chronic periodontitis (CP) is linked to sudden sensorineural hearing loss (SSNHL). This study found a significant association between prior CP diagnosis and developing SSNHL, suggesting a potential systemic connection.
Area of Science:
- Oral health and systemic disease research
- Otolaryngology and audiology research
- Inflammatory disease mechanisms
Background:
- Chronic periodontitis (CP) is linked to systemic inflammatory conditions like heart disease and cancer.
- Sudden sensorineural hearing loss (SSNHL) is a complex condition with various potential causes.
- The association between CP and SSNHL has not been previously investigated.
Purpose of the Study:
- To explore the potential association between chronic periodontitis (CP) and sudden sensorineural hearing loss (SSNHL).
- To investigate this link using a large, population-based dataset from Taiwan.
Main Methods:
- A population-based case-control study was conducted.
- Data from the Taiwan National Health Insurance program was utilized.
- 2,436 SSNHL cases and 7,308 controls were analyzed using conditional logistic regression.
Main Results:
- A significant difference in the prevalence of prior CP diagnosis was observed between SSNHL cases and controls (p < 0.001).
- Individuals with SSNHL had a 1.44 times higher odds of a previous CP diagnosis compared to controls (OR = 1.44, 95% CI = 1.29–1.63), after adjusting for comorbidities.
- The association remained significant after accounting for conditions like hypertension, diabetes, and heart disease.
Conclusions:
- This study establishes a significant association between sudden sensorineural hearing loss (SSNHL) and a prior diagnosis of chronic periodontitis (CP).
- The findings suggest a potential systemic link between oral inflammation and hearing loss.
- Further research is recommended to confirm these findings and elucidate the underlying pathological mechanisms.