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Related Concept Videos

Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

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Related Experiment Video

Updated: May 8, 2026

Generating Kidney Organoids in Suspension from Induced Pluripotent Stem Cells
07:22

Generating Kidney Organoids in Suspension from Induced Pluripotent Stem Cells

Published on: September 1, 2023

Recreating kidney progenitors from pluripotent cells.

Minoru Takasato1, Barbara Maier, Melissa H Little

  • 1Division of Molecular Genetics and Development, Institute for Molecular Biosciences, The University of Queensland, Brisbane, QLD, 4072, Australia.

Pediatric Nephrology (Berlin, Germany)
|September 13, 2013
PubMed
Summary

Generating kidney cells from human pluripotent cells is difficult but essential for regenerative medicine. This review explores embryonic kidney development to guide the creation of kidney cells from pluripotent stem cells.

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A Simplified Method for Generating Kidney Organoids from Human Pluripotent Stem Cells
07:39

A Simplified Method for Generating Kidney Organoids from Human Pluripotent Stem Cells

Published on: April 13, 2021

Related Experiment Videos

Last Updated: May 8, 2026

Generating Kidney Organoids in Suspension from Induced Pluripotent Stem Cells
07:22

Generating Kidney Organoids in Suspension from Induced Pluripotent Stem Cells

Published on: September 1, 2023

A Simplified Method for Generating Kidney Organoids from Human Pluripotent Stem Cells
07:39

A Simplified Method for Generating Kidney Organoids from Human Pluripotent Stem Cells

Published on: April 13, 2021

Area of Science:

  • Regenerative Medicine
  • Developmental Biology
  • Stem Cell Biology

Background:

  • Human pluripotent cells offer a potential source for cell therapies and bioengineering.
  • Directing differentiation of pluripotent cells into specific cell types, like renal cells, remains a significant challenge.
  • Recreating the kidney requires generating multiple distinct renal cell types, complicating in vitro efforts.

Purpose of the Study:

  • To review the embryonic development of kidney cells.
  • To assess progress in generating nephron progenitors and mature renal derivatives from pluripotent cells.
  • To bridge developmental biology insights with stem cell applications for kidney regeneration.

Main Methods:

  • Review of existing literature on embryonic kidney development.
  • Analysis of studies on directed differentiation of pluripotent stem cells towards renal lineages.
  • Synthesis of knowledge regarding cell specification and differentiation pathways.

Main Results:

  • Understanding embryonic kidney specification provides a roadmap for directed differentiation.
  • Progress has been made in generating nephron progenitors and some mature renal derivatives.
  • Challenges persist in replicating the full complexity of kidney cell types and structures.

Conclusions:

  • Embryonic kidney development provides crucial insights for stem cell-based kidney bioengineering.
  • Further research is needed to overcome challenges in generating diverse renal cell types from pluripotent sources.
  • Translating developmental knowledge holds promise for future cellular therapies for kidney disease.