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Impaired aortic distensibility in hypothyroid patients with negative coronary angiograms: simultaneous evaluation

Abdurrahim Dusak1, Gokhan Gokalp, Cuneyt Erdogan

  • 1Department of Radiology, Uludag University, Bursa, Turkey.

The Journal of International Medical Research
|September 13, 2013
PubMed

Insights

Hypothyroidism is linked to reduced aortic distensibility, indicating preclinical vascular changes. This finding highlights the importance of monitoring aortic health in hypothyroid patients to assess cardiovascular risk.

Area of Science:

  • Cardiovascular Imaging
  • Endocrinology
  • Vascular Biology

Background:

  • Hypothyroidism can affect cardiovascular health.
  • Arterial distensibility is a key indicator of vascular function.
  • Assessing aortic distensibility may reveal subclinical vascular alterations.

Purpose of the Study:

  • To investigate the relationship between hypothyroidism and aortic distensibility.
  • To simultaneously assess coronary arteries and aortic distensibility using MDCT.
  • To determine if hypothyroidism is associated with impaired aortic function.

Main Methods:

  • 128-slice retrospective electrocardiogram-gated MDCT was used.
  • Coronary angiography and aortic distensibility were assessed in hypothyroid and euthyroid patients.
  • Aortic areas were measured in systolic and diastolic phases at multiple thoracic locations.

Main Results:

  • 21 hypothyroid and 21 euthyroid patients were included.
  • Hypothyroid patients showed significantly decreased aortic distensibility.
  • Impaired distensibility was observed across all measured thoracic aorta locations.

Conclusions:

  • Hypothyroidism is associated with preclinical vascular alterations, specifically reduced aortic distensibility.
  • Impaired aortic distensibility in hypothyroidism correlates with increased cardiovascular risk.
  • Monitoring aortic distensibility is crucial for managing coronary artery disease in hypothyroid patients.
Abstract

Keywords:
Aortic distensibilityMDCTcoronary artery diseasehypothyroidismmultiple row detector computed tomography

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