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Updated: May 8, 2026
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Conversion of trans-diboran(4)yl platinum complexes into their cis-bisboryl analogues
Holger Braunschweig1, Alexander Damme, Thomas Kupfer
1Institut für Anorganische Chemie, Julius-Maximilians-Universität Würzburg, Am Hubland, 97074 Würzburg (Germany), Fax: (+49) 931-31-84623. h.braunschweig@uni-wuerzburg.de.
Abstract:
The diboran(4)yl trans-[(iPr3 P)2 Pt(Br){B(NMe2 )B(NMe2 )Br}] (1) is readily converted into its cis-bisboryl analogues 2 and 3 by reaction with the chelating bisphosphines 1,2-bis(dicyclohexylphosphino)ethane (dcpe) and 1,1-bis(dicyclohexylphosphino)methane (dcpm), respectively. A plausible mechanism of this transformation consists of a sequence of reductive diborane(4) elimination and subsequent reoxidative addition of its BB bond to the low-valent platinum centers. Thus, the forced cis configuration of the phosphine ligands induces a change in the preferred reaction site of the diborane(4) with respect to oxidative addition. The reactions proceed with high selectivities, and the cis-bisboryl complexes 2 and 3 were isolated in moderate yields (55 and 46 %). Moreover, their identity was clearly verified by NMR spectroscopy and X-ray diffraction studies.
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