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Intrainsular functional connectivity in human.

Talal Almashaikhi1, Sylvain Rheims, Karine Ostrowsky-Coste

  • 1Translational and Integrative Group in Epilepsy Research (TIGER), Lyon's Neuroscience Research Centre, INSERM U1028, CNRS 5292, UCB Lyon 1, Lyon, France; Pediatric Epilepsy Department, Hospices Civils de Lyon, Lyon, France; Department of Clinical Physiology, Neurophysiology division, Sultan Qaboos University Hospital, Muscat, Oman.

Human Brain Mapping
|September 13, 2013
PubMed
Summary
This summary is machine-generated.

Human insula connectivity reveals interconnected gyri with reciprocal connections, but no right-left communication. This supports the insula's complex integration role in cognition.

Keywords:
evoked potentialfunctional connectivityhumaninsularintra-cranial electrical stimulation

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Area of Science:

  • Neuroscience
  • Human Brain Anatomy
  • Functional Connectivity

Background:

  • The insular cortex is known for its complex cytoarchitecture and extensive connections.
  • Understanding intrainsular connections is crucial for elucidating the insula's integrative functions.
  • Limited data exists on the specific functional connectivity within the human insula.

Purpose of the Study:

  • To investigate the functional connectivity within and across insular subregions.
  • To analyze connectivity at both the gyral and functional levels in the human insula.

Main Methods:

  • Intracerebral electrical stimulation was performed in 10 epilepsy patients with depth electrodes in the insula.
  • Bipolar stimulation was delivered to insular contacts, and evoked potentials were recorded.
  • Connectivity rate was calculated based on significant evoked potentials between insular contacts.

Main Results:

  • Significant evoked potentials were observed in 74% of tested connections, with a mean latency of 26 ± 3 ms.
  • All insular gyri demonstrated interconnections, excluding the anterior and posterior short gyri.
  • Connections were predominantly reciprocal, lacking clear anterior-posterior directionality, and no inter-hemispheric connections were found.

Conclusions:

  • Human insula connectivity exhibits unique features compared to non-human primates.
  • The findings align with the insula's established role in integrating information across various cognitive domains.
  • The study highlights the complex, reciprocal intrainsular network supporting human cognition.