Improved stereochemical analysis of conformationally flexible diamines by binding to a bisporphyrin molecular clip
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Updated: May 8, 2026
Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Sara Norrehed1, Henrik Johansson, Helena Grennberg
1Uppsala University, Department of Chemistry, BMC, Box 576, 751 23 Uppsala (Sweden).
Abstract:
The relative stereochemistry of acyclic diamines with several stereogenic centers has been analyzed by NMR spectroscopy in combination with conformational deconvolution. Binding to a bisporphyrin molecular clip improves the stereochemical assignment significantly. The diamines were synthesized from inexpensive sugar alcohols, and their stable hydrochlorides were quantitatively converted into free bases by treatment with ion-exchange resin.
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