Developmental inter-relations between early maternal depression, contextual risks, and interpersonal stress, and their effect on later child cognitive functioning
Related Experiment Video
Updated: May 8, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Sarah K G Jensen1, Iroise Dumontheil, Edward D Barker
1Department of Psychology, Institute of Psychiatry, King's College London, London, United Kingdom; Department of Psychological Sciences, Birkbeck, University of London, London, United Kingdom.
Background:
Maternal depression and contextual risks (e.g. poverty) are known to impact children's cognitive and social functioning. However, few published studies have examined how stress in the social environment (i.e. interpersonal stress) might developmentally inter-relate with maternal depression and contextual risks to negatively affect a child in these domains. This was the purpose of the current study.
Method:
Mother-child pairs (n = 6979) from the Avon Longitudinal Study of Parents were the study participants. Mothers reported on depression, contextual risks, and interpersonal stress between pregnancy and 33 months child age. At age 8, the children underwent cognitive assessments and the mothers reported on the children's social cognitive skills.
Results:
Maternal depression, contextual risks, and interpersonal stress showed strong continuity and developmental inter-relatedness. Maternal depression and contextual risks directly predicted a range of child outcomes, including executive functions and social cognitive skills. Interpersonal stress worked indirectly via maternal depression and contextual risks to negatively affect child outcomes.
Conclusion:
Maternal depression and contextual risks each increased interpersonal stress in the household, which, in turn, contributed to reduced child cognitive and social functioning.
Related Concept Videos
Relationship with Parents: Attachment
Socioemotional Development during Infancy
Primary Temperament Types
Stella Chess...
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Information Processing Approach
Stress and Mental Health
Individuals with depression often experience challenges in both their personal and professional...
Psychological and Sociocultural Causes of Schizophrenia

