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Updated: May 8, 2026

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Published on: May 6, 2010
Adult neurogenesis produces neurons with unique GABAergic synapses in the olfactory bulb
Matthew T Valley1, Lansdale G Henderson, Samuel A Inverso
1Laboratory for Perception and Memory and Integrative Neurobiology of Cholinergic Systems, Pasteur Institute, F-75015 Paris, France, and National Center of Scientific Research, Coeducational Research Unit, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 3571, F-75015 Paris, France.
Abstract:
Neuronal regeneration occurs naturally in a few restricted mammalian brain regions, but its functional significance remains debated. Here we search for unique features in the synaptic outputs made by adult-born granule cell interneurons in the mouse olfactory bulb using optogenetic targeting of specific neuronal ages. We find that adult-born interneurons are resistant to presynaptic GABA(B)-mediated depression of GABA release compared with interneurons born just after birth that exhibit strong GABA(B) neuromodulation. Correlated with this functional change, we found altered localization of the GGABA(B)R1 protein within adult-born granule cells. These results suggest that adult neurogenesis produces a population of functionally unique GABAergic synapses in the olfactory bulb.
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