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Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals
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Neonatal herpes simplex fulminant hepatitis successfully treated with acyclovir.

Said D Abuhasna1, Zuhair M Shihab, Shaikha M Al Niyadi

  • 1Department of Critical Care Medicine, Tawam Hospital, P. O. Box 15258, Al Ain, United Arab Emirates.

Journal of Clinical Neonatology
|September 13, 2013
PubMed
Summary

Disseminated neonatal herpes simplex virus (HSV) infection can be fatal. This report details the first survival of a neonate with severe HSV-2 liver failure without a transplant.

Keywords:
Disseminated herpes simplexliver failureneonate

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Area of Science:

  • Neonatal Medicine
  • Virology
  • Hepatology

Background:

  • Neonatal herpes simplex virus (HSV) infection presents a severe health risk, with disseminated forms leading to organ failure and high mortality.
  • Both HSV-1 and HSV-2 can cause neonatal herpes, posing significant challenges in diagnosis and treatment.

Observation:

  • A case of disseminated neonatal herpes was observed, specifically linked to severe, rapidly progressing liver failure.

Findings:

  • The infection was caused by herpes simplex virus type 2 (HSV-2).
  • The neonate experienced fulminant liver failure but survived the infection without requiring a liver transplant, a first documented instance.

Implications:

  • This case highlights the potential for survival in severe neonatal HSV-2 liver failure with appropriate management.
  • It suggests that liver transplantation may not always be necessary for neonatal HSV-2-induced liver failure.
  • Further research into treatment strategies for severe neonatal HSV infections affecting the liver is warranted.