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Related Concept Videos

Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Bacterial Phylum Chlamydiae01:29

Bacterial Phylum Chlamydiae

The phylum Chlamydiae or Chlamydiota is composed of a single order, Chlamydiales. This phylum consists entirely of obligate intracellular parasites that infect eukaryotic hosts. While human pathogens within this group have been studied extensively, the phylum encompasses many species capable of interacting with various eukaryotic organisms. Members of Chlamydiae are typically small cocci, approximately 0.5 μm in diameter, and exhibit a distinctive developmental cycle. As is characteristic of...

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Related Experiment Video

Updated: May 8, 2026

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1
06:18

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Published on: March 13, 2018

Congenital chikungunya.

Hariharan Gopakumar1, Sivji Ramachandran

  • 1Department of Pediatrics and Neonatology, Amrita Institute of Medical Sciences, Kochi, Kerala, India.

Journal of Clinical Neonatology
|September 13, 2013
PubMed
Summary
This summary is machine-generated.

Chikungunya virus (CHIKV) infection in newborns is rare but can cause severe thrombocytopenia and multisystem issues. Early identification is crucial for proper management and predicting outcomes in affected infants.

Keywords:
Acute renal failurechikungunyaneonatesthrombocytopenia

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Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult
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Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult

Published on: April 26, 2018

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Last Updated: May 8, 2026

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1
06:18

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Published on: March 13, 2018

Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult
09:39

Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult

Published on: April 26, 2018

Area of Science:

  • Virology
  • Neonatology
  • Infectious Diseases

Background:

  • Chikungunya virus (CHIKV) infection is an emerging arboviral disease with significant public health implications.
  • Neonatal manifestation of CHIKV infection is exceptionally rare, with limited documented cases and understanding of its clinical spectrum.
  • Recent reports highlight the increasing recognition of CHIKV in neonates, necessitating further investigation into its unique presentation and impact.

Observation:

  • This case report details a rare instance of CHIKV infection in a neonate.
  • The neonate presented with severe thrombocytopenia, a significant drop in platelet count.
  • Multisystem involvement was observed, indicating a severe systemic response to the viral infection.

Findings:

  • The neonate exhibited clinical signs consistent with severe CHIKV infection.
  • Laboratory findings revealed profound thrombocytopenia as a key complication.
  • Evidence of involvement across multiple organ systems underscored the severity of the illness.

Implications:

  • Recognizing CHIKV infection in neonates is critical for timely diagnosis and intervention.
  • Understanding the clinical presentation, including severe thrombocytopenia and multisystem involvement, aids in effective patient management.
  • Accurate diagnosis and prognostication based on clinical and epidemiological context are vital for improving outcomes in affected neonates.