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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Assessment of volume status and arterial stiffness in chronic kidney disease

Hakan Akdam1, Handan Öğünç, Alper Alp

  • 1Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Adnan Menderes University , Aydın , Turkey .

Renal Failure
|September 14, 2013
PubMed

Insights

Arterial stiffness, measured by pulse wave velocity (PWV), is increased in chronic kidney disease (CKD) patients. Overhydration may contribute to this arterial stiffness in CKD and continuous ambulatory peritoneal dialysis (CAPD) patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Vascular Physiology

Background:

  • Arterial stiffness is an independent risk factor for cardiovascular events.
  • Limited data exists on arterial stiffness in advanced chronic kidney disease (CKD).
  • Pulse wave velocity (PWV) and augmentation index (AIx) are key markers of arterial stiffness.

Purpose of the Study:

  • To investigate arterial stiffness (PWV, AIx) and volume status in patients with stage 3B-5 CKD and continuous ambulatory peritoneal dialysis (CAPD).
  • To identify factors contributing to increased arterial stiffness in this patient population.

Main Methods:

  • Sixty-six patients with stage 3B-5 CKD, 21 CAPD patients, and 34 healthy controls were enrolled.
  • Pulse wave velocity (PWV), augmentation index (AIx), and volume status were assessed using Mobil-O-Graph® and bioimpedance spectroscopy.
  • Extracellular fluid excess and overhydration were quantified.

Main Results:

  • Median PWV was significantly higher in CKD patients (7.5 m/s) compared to CAPD (6.2 m/s) and healthy controls (5.9 m/s).
  • AIx values were similar across all groups.
  • Overhydration and extracellular fluid excess were significantly more prevalent in both CKD and CAPD patients.

Conclusions:

  • Stage 3B-5 CKD patients exhibit increased PWV, indicating heightened arterial stiffness.
  • Overhydration is a significant contributing factor to the elevated PWV observed in CKD and CAPD patients.
  • PWV is influenced by age, blood pressure, body composition, overhydration, CKD status, and eGFR.
Abstract

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