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Updated: May 8, 2026
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Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
Angioedema without urticaria in childhood.
Hacer I Ertoy Karagol1, Ozlem Yilmaz, Arzu Bakirtas
1Department of Pediatric Allergy and Asthma, Gazi University School of Medicine, Ankara, Turkey.
Summary
Angioedema without urticaria (Aw/oU) is rare in children, with infections and allergies being common causes. Antihistamine treatment is effective for recurrent, non-hereditary cases, showing a good short-term prognosis.
Area of Science:
- Pediatric Allergy and Immunology
- Dermatology
- Clinical Research
Background:
- Angioedema without urticaria (Aw/oU) has not been previously studied exclusively in pediatric populations.
- Understanding Aw/oU in children is crucial for accurate diagnosis and management.
Purpose of the Study:
- To investigate the frequency, clinical presentation, etiology, management, and follow-up of angioedema without urticaria in children.
- To establish a baseline for pediatric Aw/oU research.
Main Methods:
- Prospective study of consecutive pediatric patients with Aw/oU referred to a specialized clinic from January 2011 to May 2012.
- Application of a standardized diagnostic and therapeutic algorithm for all included patients.
Main Results:
- Aw/oU represented 1.6% of cases during the study period.
- Identifiable causes included infection (21%), allergy (14%), thyroid autoimmunity (8%), and NSAID hypersensitivity (6%), with 51% being idiopathic.
- No hereditary or acquired angioedema types or rare syndromes were observed.
Conclusions:
- Angioedema without urticaria is a rare pediatric condition, often with an unidentified etiology.
- Antihistamine monotherapy appears sufficient for managing recurrent, non-hereditary cases, demonstrating a favorable short-term prognosis.
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