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Does decreased mean platelet volume predict inflammation in chronic renal failure, dialysis, and transplanted
Yusuf Bilen1, Erdem Cankaya, Mustafa Keles
1Department of Hematology .
Insights
Mean platelet volume (MPV) did not differ significantly across chronic kidney disease (CKD) patient groups. However, hemodialysis patients showed higher C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels, indicating greater inflammation.
Area of Science:
- Nephrology
- Cardiovascular Medicine
- Inflammation Research
Background:
- Increased platelet activation is linked to cardiovascular mortality in chronic kidney disease (CKD).
- Larger platelets, indicated by mean platelet volume (MPV), are more active and proposed as cardiovascular disease biomarkers.
- This study examines MPV as an inflammatory marker across diverse CKD patient populations, including those on renal replacement therapies.
Purpose of the Study:
- To evaluate mean platelet volume (MPV) as an inflammatory marker in a broad spectrum of chronic kidney disease (CKD) patients.
- To compare inflammatory markers, including MPV, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR), across different CKD stages and renal replacement therapies.
- To assess the potential of renal replacement therapies to modulate inflammation in CKD patients.
Main Methods:
- A cohort of 200 CKD patients was studied, encompassing renal transplant recipients (50), hemodialysis (HD) patients (50), peritoneal dialysis (PD) patients (50), and chronic renal failure stages 3-4 patients (50).
- Data collected included demographic information, platelet count, MPV, CRP, ESR, and hemoglobin levels.
- All patients had undergone at least 12 months of their respective renal replacement therapy or management.
Main Results:
- Hemodialysis (HD) patients exhibited statistically significant higher mean C-reactive protein (CRP) levels compared to renal transplant, peritoneal dialysis (PD), and pre-dialysis chronic renal failure groups (p < 0.01).
- Mean CRP levels were also significantly higher in the pre-dialysis group compared to transplanted and PD patients (p < 0.01).
- No statistically significant differences were observed in mean platelet volume (MPV) among all patient groups (p > 0.05).
Conclusions:
- Hemodialysis patients demonstrated significantly elevated ESR and CRP levels compared to other CKD groups, indicating heightened inflammation.
- Mean platelet volume (MPV) did not show significant differences across the studied CKD patient groups.
- Renal transplantation emerged as a favorable renal replacement therapy, associated with the lowest ESR levels and reduced inflammation.
Objectives:
Increased platelet activation contributes to cardiovascular mortality in chronic kidney disease patients (CKD). Larger platelets are more active and this increased activity had been suggested as a predictive biomarker for cardiovascular disease. In this study, we aimed to evaluate mean platelet volume (MPV) as an inflammatory marker in a broadened group of CKD patients. Our study is unique in literature as it covers all types of CKD including renal replacement therapies.
Materials And Methods:
200 patients (50 renal transplanted, 50 hemodialysis, 50 peritoneal dialysis, 50 chronic renal failure stages 3-4) were investigated who were between 18 and 76 years of age. The collected data included demographic properties, platelet count, MPV, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and hemoglobin. All of the patients had at least 12 month of therapy of either renal replacement modality.
Results:
The mean CRP value was detected statistically significantly higher in hemodialysis (HD) patients compared to the resting three groups of patients (p < 0.01). Mean CRP level was detected significantly higher in the pre-dialysis group compared to transplanted and peritoneal dialysis (PD) patients (p < 0.01). There is no statistically significant difference detected among the mean MPV values of all patient groups (p > 0.05).
Conclusions:
ESR and CRP were significantly increased in hemodialysis patients compared to the other groups. We did not detect a significant difference among MPV between the groups. ESR was detected lowest in transplanted patients. Transplantation is coming forward as the favorable choice of renal replacement therapy which decreases inflammation.
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