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Related Experiment Video

Updated: May 7, 2026

Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR

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Published on: February 4, 2018

[Lyme arthritis in children: a diagnostic trap].

J Leroux¹, P-H Vivier, M Grall

¹Clinique chirurgicale infantile, université de Rouen, CHU de Rouen, 1, rue de Germont, 76031 Rouen cedex, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie

|September 14, 2013

Summary

Lyme arthritis in children can mimic septic or rheumatoid arthritis, leading to delayed diagnosis. Consider Lyme disease even in low-incidence areas for accurate pediatric care.

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Simultaneous Detection of Different Antibody Classes in a Multiplexed Serological Test

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Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR

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Published on: February 4, 2018

Simultaneous Detection of Different Antibody Classes in a Multiplexed Serological Test

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Published on: July 14, 2023

Area of Science:

Pediatric Rheumatology
Infectious Diseases
Epidemiology

Background:

Lyme disease incidence varies across France, with higher prevalence in Central and Eastern regions.
Arthritis is a common late manifestation of Lyme disease, particularly in children.
Pediatric Lyme arthritis often presents symptoms similar to septic arthritis and juvenile rheumatoid arthritis.

Observation:

An 8-year-old girl in a low-incidence Lyme disease area presented with knee arthritis initially diagnosed as septic arthritis.
Worsening clinical and biological signs after six days prompted a reevaluation of the diagnosis.
Lyme arthritis was confirmed via serological testing.

Findings:

The case highlights diagnostic challenges in pediatric Lyme arthritis due to overlapping symptoms with more common conditions.
Prompt serological confirmation enabled timely adaptation of treatment.
The patient showed positive progression after appropriate Lyme disease treatment.

Implications:

Pediatric Lyme arthritis should be considered in the differential diagnosis of childhood arthritis, irrespective of geographic incidence.
Early and accurate diagnosis of Lyme arthritis is crucial for effective management and preventing long-term complications.
Raising awareness among clinicians about Lyme arthritis mimics is essential for improving pediatric patient outcomes.