Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Symbiosis

Symbiosis

Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...

Diversity of Protists II

Diversity of Protists II

Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Prevalence of molecular markers related to artemisinin partial resistance and ACT partner drug resistance in the Plasmodium falciparum population in Kongo Central, DRC.

Malaria journal·2026

Same author

Population expectations of primary care quality in 18 countries: a cross-sectional analysis of data from the People's Voice Survey.

The Lancet. Primary care·2026

Same author

Health system use and experience among people with poor mental health: A cross-sectional analysis of the People's Voice Survey in 18 countries.

PLoS medicine·2026

Same author

Piloting the feasibility of a population-based joint TB-HIV survey in KwaZulu-Natal Province, South Africa, 2019.

PLOS global public health·2026

Same author

Parasite clearance and protection from Plasmodium falciparum infection (PCPI): a two-arm, parallel, double-blinded, placebo-controlled, randomised trial of presumptive sulfadoxine-pyrimethamine versus artesunate monotherapy among asymptomatic children 3-5 years of age in Zambia.

BMC infectious diseases·2025

Same author

Psychological distress in South Africa: Analysis of 2017 national household survey data.

Health SA = SA Gesondheid·2025

Search research articles

Related Experiment Video

Updated: May 7, 2026

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Published on: December 4, 2015

Mapping 'partially resistant', 'fully resistant', and 'super resistant' malaria.

Inbarani Naidoo¹, Cally Roper

¹Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK; Malaria Research Unit, Medical Research Council, PO Box 70380 Overport 4067, South Africa.

Trends in Parasitology

|September 14, 2013

Summary

Sulfadoxine-pyrimethamine (SP) resistance threatens malaria prevention in Africa. Regional genetic differences in dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutations show varying resistance levels, impacting treatment efficacy.

Keywords:

drug resistance intermittent preventive treatment (IPT)malaria sulfadoxine–pyrimethamine (SP)super resistance

More Related Videos

A Multi-detection Assay for Malaria Transmitting Mosquitoes

A Multi-detection Assay for Malaria Transmitting Mosquitoes

Published on: February 28, 2015

Protocol for Production of a Genetic Cross of the Rodent Malaria Parasites

Protocol for Production of a Genetic Cross of the Rodent Malaria Parasites

Published on: January 3, 2011

Related Experiment Videos

Last Updated: May 7, 2026

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Published on: December 4, 2015

A Multi-detection Assay for Malaria Transmitting Mosquitoes

A Multi-detection Assay for Malaria Transmitting Mosquitoes

Published on: February 28, 2015

Protocol for Production of a Genetic Cross of the Rodent Malaria Parasites

Protocol for Production of a Genetic Cross of the Rodent Malaria Parasites

Published on: January 3, 2011

Area of Science:

Malariology
Genetics
Public Health

Background:

Sulfadoxine-pyrimethamine (SP) is a key antimalarial drug used for intermittent preventive treatment (IPT) in Africa.
Growing resistance to SP poses a significant threat to its continued efficacy in malaria control programs.

Purpose of the Study:

To map recent surveys of dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutations.
To identify regional genetic differences in SP resistance across Africa.
To assess the impact of these mutations on SP efficacy.

Main Methods:

Analysis of recent survey data on dhfr and dhps mutations.
Genotyping of parasite populations to identify specific resistance-conferring mutations.
Correlation of mutation profiles with reported SP treatment failures.

Main Results:

Significant regional variations in SP resistance genotypes were observed.
West Africa shows a 'partially resistant' profile (dhfr N51I, N59R, S108N with dhps A437G).
East Africa exhibits a 'fully resistant' profile (dhfr N51I, N59R, S108N with dhps A437G+K540E).
Three East African foci display 'super resistance' with additional dhps 581G and/or dhfr 164L mutations.
SP-IPT failures reported in 'super resistant' areas.

Conclusions:

Regional genetic diversity in malaria parasite resistance genes (dhfr, dhps) significantly impacts SP efficacy.
The emergence of 'super resistant' strains necessitates a review of SP-IPT strategies in affected regions.
Understanding resistance patterns is crucial for maintaining effective malaria prevention and control.