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Radiological findings in gliosarcoma. A single institution experience
M Y Swaidan1, M Hussaini, I Sultan
1King Hussein Cancer Center; Amman, Jordan - amansour@khcc.jo.
The Neuroradiology Journal
|September 14, 2013
Summary
Gliosarcomas, rare brain tumors with glial and sarcoma elements, often involve the dura or ependyma. Imaging may show calcification, hemorrhage, or cystic changes with ring enhancement.
Area of Science:
- Neuro-oncology
- Radiology
- Pathology
Background:
- Gliosarcomas are rare, aggressive brain tumors comprising malignant glial and sarcoma components.
- They represent a small percentage of malignant astrocytic neoplasms, with limited research on their imaging characteristics.
Purpose of the Study:
- To review and describe the imaging findings of gliosarcoma.
- To identify potential radiological patterns associated with this rare tumor type.
Main Methods:
- Retrospective review of imaging studies (MRI/CT) from eight gliosarcoma patients treated between 2002 and 2010.
- Diagnosis confirmation through morphological and immunohistochemical analysis.
Main Results:
- No unique radiological features were identified for gliosarcoma.
- Consistent findings included dural and/or ependymal involvement in all cases.
- Commonly observed features were calcification, hemorrhage, cystic components, and ring enhancement.
Conclusions:
- While gliosarcoma lacks specific imaging biomarkers, dural/ependymal involvement is a notable characteristic.
- Radiological findings like calcification, hemorrhage, and ring enhancement can aid in diagnosis.
- Further research is needed to fully elucidate the imaging spectrum of gliosarcoma.
