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Evidence for natural killer cell memory.
1Department of Molecular and Cell Biology, and Cancer Research Laboratory University of California, Berkeley, Berkeley, CA 94720-3200, USA.
Current Biology : CB
|September 14, 2013
Summary
Natural killer (NK) cells show adaptive immunity features, responding specifically to antigens and enhancing responses upon re-exposure. Studies suggest NK cells may possess memory capabilities, similar to T and B cells.
Area of Science:
- Immunology
- Cell Biology
Background:
- Natural killer (NK) cells are traditionally classified within the innate immune system.
- Emerging evidence indicates NK cells possess characteristics typically associated with adaptive immunity.
Purpose of the Study:
- To investigate the adaptive immune features of NK cells.
- To explore the antigen-specific responses and memory potential of NK cells.
Main Methods:
- Analysis of NK cell responses to various small molecules and viruses.
- Examination of NK cell behavior during mouse cytomegalovirus (MCMV) infections.
- Assessment of NK cell function under inflammatory conditions induced by cytokines.
Main Results:
- NK cells demonstrate antigen-specific responses to certain molecules and viruses.
- MCMV-specific NK cells undergo clonal expansion and enhanced effector function post-infection.
- Cytokine-induced inflammation can prolong NK cell effector function in an antigen-non-specific manner.
Conclusions:
- NK cells exhibit antigen-specific responses and may possess memory functions akin to T and B cells.
- NK cells display a greater capacity for antigen discrimination than previously understood.
- These findings redefine aspects of NK cell biology and their role in immunity.
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