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Paget's Disease. A Case Report.

R Conforti1, R Galasso, V Marrone

  • 1Magrassi Lanzara Department, Second University of Naples; Naples, Italy - rosario82rg@hotmail.it.

The Neuroradiology Journal
|September 14, 2013
PubMed
Summary
This summary is machine-generated.

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Paget

Area of Science:

  • Orthopedics
  • Radiology
  • Pathology

Background:

  • Paget's disease (PD) is a common, focal, progressive osteometabolic disorder affecting bone modeling and remodeling.
  • Its etiology is unknown, impacting ~3% of individuals over 40, with prevalence increasing with age.
  • PD is most common in Northern Europe and Australia, and rare in Asia and Africa.

Purpose of the Study:

  • To describe a case of Paget's disease confined to the sacrum in an elderly male.
  • To highlight the diagnostic imaging findings and pathological confirmation of PD in an uncommon site.
  • To emphasize the importance of considering PD in elderly patients with spinal pain.

Main Methods:

  • A case study of a 71-year-old man diagnosed with Paget's disease.
  • Diagnostic workup included laboratory tests, radiography, scintigraphy, computed tomography (CT), and magnetic resonance imaging (MRI).

Related Experiment Videos

  • Diagnosis was confirmed via biopsy.

    • Main Results:

    • Imaging revealed findings consistent with Paget's disease in its intermediate pathological phase, localized to the sacrum.
    • CT demonstrated structural sacral modifications: rarefaction of spongiosa, bone thickening, and intact cortical bone.
    • MRI showed substitution of red marrow by fatty marrow, characteristic of PD's intermediate phase.

    Conclusions:

    • Paget's disease of the sacrum can present in elderly males and is diagnosable through a combination of imaging and biopsy.
    • Radiologists must consider PD in atypical locations, correlating imaging with clinical symptoms for accurate diagnosis and management.
    • Prompt treatment relieved the patient's pain, underscoring the importance of timely intervention for Paget's disease.