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In Vitro Drug Screening Against All Life Cycle Stages of Trypanosoma cruzi Using Parasites Expressing β-galactosidase

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Published on: November 5, 2021

Can we heal Chagas infection?

S P Vega Royero¹, G J Sibona

¹IFEG - CONICET and FAMAF, Universidad Nacional de Córdoba, Medina Allende s/n, 5000 Córdoba, Argentina.

Journal of Theoretical Biology

|September 14, 2013

Summary

Pre-infection with Trypanosoma rangeli (T. rangeli) temporarily protects against Chagas disease by priming the immune system. However, T. rangeli clearance reduces antibody levels, highlighting the need for repeated vaccination strategies.

Keywords:

Chagas disease Mathematical modeling Trypanosoma cruzi Trypanosoma rangeli

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Area of Science:

Parasitology
Immunology
Mathematical Modeling

Background:

Trypanosoma rangeli (T. rangeli) is a parasite that infects mammals.
Chagas disease is caused by Trypanosoma cruzi.
The immune response to T. rangeli infection involves antibody production.

Purpose of the Study:

To model the dynamical competition between T. rangeli and host antibodies during acute infection.
To investigate the protective effect of T. rangeli pre-infection against Chagas disease.
To explore vaccination strategies using T. rangeli.

Main Methods:

Development of a mathematical model simulating parasite-antibody dynamics.
Validation of the model using experimental data from murine models.
Analysis of the model to predict immune system responses and protective effects.

Main Results:

The model successfully reproduces experimental data on T. rangeli infection dynamics.
Pre-infection with T. rangeli confers a temporary protective effect against Chagas disease.
Host antibody levels, crucial for Chagas resistance, decrease over time post-T. rangeli clearance.

Conclusions:

T. rangeli pre-infection can induce a transient protective immune state against Chagas disease.
The protective effect wanes as antibody levels decline, necessitating sustained immune stimulation.
Repeated vaccination with T. rangeli in domestic animals may reduce vectorial parasitemia, offering a novel control strategy.