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Updated: Aug 6, 2026

05:53
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
[The genetic markers of psoriasis]
Vestnik Dermatologii I Venerologii
|January 1, 1990
Summary
Human Leukocyte Antigen (HLA) typing in 220 psoriasis patients revealed specific antigen associations. HLA-B13 and HLA-B17 showed increased relative risk, suggesting potential for predicting disease course.
Area of Science:
- Immunogenetics
- Dermatology
Background:
- Psoriasis is a chronic inflammatory skin condition with a complex etiology.
- Genetic factors, particularly Human Leukocyte Antigen (HLA) genes, are implicated in psoriasis susceptibility and severity.
Purpose of the Study:
- To investigate the association between specific HLA-A, B, and C antigens and psoriasis in a cohort of patients.
- To determine the relative risk of certain HLA antigens in relation to psoriasis.
Main Methods:
- Utilized Terasaki and McLelland's lymphocytotoxic method for HLA antigen typing.
- Analyzed HLA-A, B, and C antigen distribution in 220 psoriasis patients.
Main Results:
- Identified significant associations between psoriasis and specific HLA antigens.
- Estimated a relative risk of 5.3 for HLA-B13 and 7.7 for HLA-B17 in psoriasis patients.
Conclusions:
- The distribution patterns of histocompatibility antigens in psoriasis patients suggest a genetic predisposition.
- HLA typing may serve as a predictive tool for the course, pattern, and clinical presentation of psoriasis.
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