Jove
Visualize
Contact Us

Related Experiment Video

Updated: Jun 28, 2026

Impulsive Pressurization of Neuronal Cells for Traumatic Brain Injury Study
09:24

Impulsive Pressurization of Neuronal Cells for Traumatic Brain Injury Study

Published on: October 12, 2011

Experiments with volume overload in SHR/Frid and WKY/Frid.

E Rohde1, E Karasek, R Buske

  • 1Institute of Drug Research, GDR Academy of Sciences, Berlin.

Zeitschrift Fur Versuchstierkunde
|January 1, 1990
PubMed
Summary

This study investigated cardiovascular responses to volume overload in hypertensive (SHR) and normotensive (WKY) rats. Hypertensive rats showed altered drug responses, indicating their utility for cardiovascular drug screening.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differential fluorescence nanoparticle tracking analysis for enumeration of the extracellular vesicle content in mixed particulate solutions.

Methods (San Diego, Calif.)·2020
Same author

International Forum on GMP-grade human platelet lysate for cell propagation: summary.

Vox sanguinis·2017
Same author

International Forum on GMP-grade human platelet lysate for cell propagation.

Vox sanguinis·2017
Same author

Red blood cell alloimmunization in 184 patients with myeloid neoplasms treated with azacitidine - A retrospective single center experience.

Leukemia research·2017
Same author

T-cell death, phosphatidylserine exposure and reduced proliferation rate to validate extracorporeal photochemotherapy.

Vox sanguinis·2014
Same author

Incidence of pertussis in patients of general practitioners in Poland.

Epidemiology and infection·2013
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Cardiovascular Physiology
  • Pharmacology
  • Animal Models

Background:

  • Chronic hypertension impacts cardiovascular system function.
  • Volume overload is a critical stressor for the heart.
  • Understanding strain-specific responses is crucial for cardiovascular research.

Purpose of the Study:

  • To compare the cardiovascular responses to acute volume overload between spontaneously hypertensive rats (SHR) and WKY rats.
  • To evaluate the utility of the SHR model for screening cardiovascular drugs under combined hypertension and volume overload conditions.

Main Methods:

  • Continuous measurement of heart rate, blood pressure, and left ventricular pressure in SHR and WKY rats.
  • Determination of contractility index (dp/dtmax).
  • Administration of Dopamine to assess drug response.

Main Results:

  • Volume overload caused a significant increase in end-diastolic left ventricular pressure in WKY rats.
  • SHR rats exhibited a diminished response to Dopamine compared to WKY rats.
  • The SHR model demonstrated a unique response profile to combined chronic hypertension and acute volume overload.

Conclusions:

  • The SHR model, subjected to volume overload, presents a distinct cardiovascular profile.
  • This model is suitable for basic circulation research and screening novel cardiovascular drugs.
  • High technical and preparative effort is required for this experimental model.

More Related Videos

Observing the Transformation of Bodily Self-consciousness in the Squeeze-machine Experiment
07:20

Observing the Transformation of Bodily Self-consciousness in the Squeeze-machine Experiment

Published on: March 8, 2019

Evaluation of Fluid Overload by Bioelectrical Impedance Vectorial Analysis
07:17

Evaluation of Fluid Overload by Bioelectrical Impedance Vectorial Analysis

Published on: August 17, 2022

Related Experiment Videos

Last Updated: Jun 28, 2026

Impulsive Pressurization of Neuronal Cells for Traumatic Brain Injury Study
09:24

Impulsive Pressurization of Neuronal Cells for Traumatic Brain Injury Study

Published on: October 12, 2011

Observing the Transformation of Bodily Self-consciousness in the Squeeze-machine Experiment
07:20

Observing the Transformation of Bodily Self-consciousness in the Squeeze-machine Experiment

Published on: March 8, 2019

Evaluation of Fluid Overload by Bioelectrical Impedance Vectorial Analysis
07:17

Evaluation of Fluid Overload by Bioelectrical Impedance Vectorial Analysis

Published on: August 17, 2022