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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

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Related Experiment Video

Updated: May 7, 2026

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
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Tau immunotherapy and imaging.

Einar M Sigurdsson1

  • 1Department of Neuroscience and Physiology, New York University School of Medicine, New York, N.Y., USA.

Neuro-Degenerative Diseases
|September 14, 2013
PubMed
Summary
This summary is machine-generated.

Tau immunotherapy shows promise for treating Alzheimer's disease (AD) and other tauopathies by reducing tau pathology and improving cognitive function. This approach targets tau, which correlates better with dementia severity than amyloid-beta plaques.

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Area of Science:

  • Neuroscience
  • Immunology
  • Pharmacology

Background:

  • Recent Alzheimer's disease (AD) trials focusing on amyloid-beta (Aβ) immunotherapy yielded disappointing results.
  • Tau pathology correlates more strongly with dementia severity than Aβ plaque burden, making tau a more promising therapeutic target for symptomatic AD.
  • Tau immunotherapy has been investigated for over a decade to address functional impairments in tauopathies.

Purpose of the Study:

  • To investigate the efficacy of active and passive tau immunizations in reducing tau pathology and improving function in mouse models of tauopathies.
  • To explore the mechanisms by which tau immunotherapies exert their effects, including both extracellular and intracellular pathways.
  • To establish the feasibility of tau immunotherapy for clinical trials and develop diagnostic tools for tauopathies.

Main Methods:

  • Utilized various active and passive tau immunization strategies in different mouse models.
  • Investigated antibody internalization and clearance mechanisms in neuronal and cell culture models.
  • Confirmed findings across multiple independent laboratories and models.

Main Results:

  • Tau immunizations effectively diminished tau pathology and improved cognitive and functional outcomes in preclinical models.
  • Evidence suggests antibodies facilitate tau clearance through microglial phagocytosis and neuronal lysosomal degradation.
  • Antibody internalization was observed in various in vivo and in vitro models, including brain slices and neuronal cultures.

Conclusions:

  • Tau immunotherapy is a feasible and promising therapeutic strategy for Alzheimer's disease and other tauopathies.
  • Targeting tau pathology offers a viable alternative to Aβ-focused treatments, particularly for patients with cognitive impairment.
  • Development of diagnostic imaging tools is crucial for monitoring tau pathology and treatment efficacy.