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Time dependence of cisplatin-induced duplex dissociation of 15-mer RNAs and mature miR-146a
Christopher Polonyi1, Sofi K C Elmroth
1Biochemistry and Structural Biology, KILU, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden. sofi.elmroth@biochemistry.lu.se.
Dalton Transactions (Cambridge, England : 2003)
|September 14, 2013
Abstract:
The kinetics for the binding of cisplatin to duplex RNAs, two fully complementary model systems and mature miR-146a, exhibits a linear dependence on cisplatin concentration and results in duplex dissociation at 38 °C.
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