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Risk factors for thrombosis in Serbian children.

Olivera M Serbic-Nonkovic¹, Milos B Kuzmanovic, Ljiljana B Rakicevic

¹aPediatric Clinic, Mother and Child Health Institute, 'Dr Vukan Cupic' bUniversity of Belgrade Institute of Molecular Genetics and Genetic Engineering cUniversity of Belgrade School of Medicine, Belgrade, Serbia.

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis

|September 14, 2013

Summary

Pediatric thrombosis is multifactorial, with inherited factors like Factor V Leiden and lupus anticoagulant antibodies increasing risk. Underlying medical conditions (comorbidity) are strongly associated with both venous and arterial thrombosis in children.

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Area of Science:

Pediatric Hematology
Thrombosis Research
Genetics

Background:

Venous and arterial thromboses are recognized as significant health issues in pediatric patients.
Understanding the risk factors for thrombosis in children is crucial for effective prevention and management.

Purpose of the Study:

To investigate the role of inherited thrombophilic risk factors and comorbidity in pediatric thrombosis.
To determine the independent risk factors contributing to venous and arterial thrombosis in children.

Main Methods:

A case-control study was conducted involving 129 pediatric patients (from neonates to 18 years old).
Analysis included inherited and acquired risk factors, thrombophilic profiles, and comorbidities.
Statistical methods were used to identify independent risk factors and their associations with thrombosis.

Main Results:

87.2% of children had recognized thrombophilic and/or comorbid risk factors.
Independent risk factors identified were Factor V Leiden mutation, lupus anticoagulant antibodies, and comorbidity.
Factor V Leiden mutation was a risk factor for venous thrombosis (OR, 6.2). Lupus anticoagulant antibodies were linked to both venous and arterial thrombosis.
Comorbidity was strongly associated with both venous (OR, 18.6) and arterial thrombosis (OR, 10.5).

Conclusions:

Pediatric thrombosis is a multifactorial disorder.
Comorbidity is a major contributing factor to thrombosis in children.
Inherited thrombophilic disorders play a role in the development of thrombosis in the pediatric population.