Related Experiment Video

Updated: May 7, 2026

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
07:09

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

Published on: April 1, 2015

Risk factors for thrombosis in Serbian children

Olivera M Serbic-Nonkovic1, Milos B Kuzmanovic, Ljiljana B Rakicevic

  • 1aPediatric Clinic, Mother and Child Health Institute, 'Dr Vukan Cupic' bUniversity of Belgrade Institute of Molecular Genetics and Genetic Engineering cUniversity of Belgrade School of Medicine, Belgrade, Serbia.

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|September 14, 2013
PubMed

Insights

Pediatric thrombosis is multifactorial, with inherited factors like Factor V Leiden and lupus anticoagulant antibodies increasing risk. Underlying medical conditions (comorbidity) are strongly associated with both venous and arterial thrombosis in children.

Area of Science:

  • Pediatric Hematology
  • Thrombosis Research
  • Genetics

Background:

  • Venous and arterial thromboses are recognized as significant health issues in pediatric patients.
  • Understanding the risk factors for thrombosis in children is crucial for effective prevention and management.

Purpose of the Study:

  • To investigate the role of inherited thrombophilic risk factors and comorbidity in pediatric thrombosis.
  • To determine the independent risk factors contributing to venous and arterial thrombosis in children.

Main Methods:

  • A case-control study was conducted involving 129 pediatric patients (from neonates to 18 years old).
  • Analysis included inherited and acquired risk factors, thrombophilic profiles, and comorbidities.
  • Statistical methods were used to identify independent risk factors and their associations with thrombosis.

Main Results:

  • 87.2% of children had recognized thrombophilic and/or comorbid risk factors.
  • Independent risk factors identified were Factor V Leiden mutation, lupus anticoagulant antibodies, and comorbidity.
  • Factor V Leiden mutation was a risk factor for venous thrombosis (OR, 6.2). Lupus anticoagulant antibodies were linked to both venous and arterial thrombosis.
  • Comorbidity was strongly associated with both venous (OR, 18.6) and arterial thrombosis (OR, 10.5).

Conclusions:

  • Pediatric thrombosis is a multifactorial disorder.
  • Comorbidity is a major contributing factor to thrombosis in children.
  • Inherited thrombophilic disorders play a role in the development of thrombosis in the pediatric population.

More Related Videos

Venous Thrombosis Assay in a Mouse Model of Cancer04:40

Venous Thrombosis Assay in a Mouse Model of Cancer

Published on: January 5, 2024

Related Concept Videos

Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Varicose Veins I: Introduction01:26

Varicose Veins I: Introduction

Varicose veins, or varicosities, are abnormally dilated and twisted superficial veins caused by venous valve incompetence. This condition commonly affects the lower extremities, especially the saphenous veins, due to the higher pressure from prolonged standing and walking. However, varicosities can also occur in other areas, such as the esophagus, vulva, spermatic cords, and anorectal region.Etiology and typesPrimary varicose veins, often idiopathic, are more common in women due to inherent...